doi: 10.1021/ol990240n.
Solid-phase enzymatic synthesis of oligonucleotides
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- PMID: 10836032
- DOI: 10.1021/ol990240n
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Solid-phase enzymatic synthesis of oligonucleotides
Org Lett.
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Abstract
[formula: see text] The controlled and selective synthesis of oligonucleotides on the solid phase is possible under mild aqueous conditions using the enzyme T4 RNA ligase, the resins being tentagel or kieselguhr/polydimethylacrylamide.
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