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. 1999 Dec 2;1(11):1729-31.
doi: 10.1021/ol990240n.

Solid-phase enzymatic synthesis of oligonucleotides

C Schmitz  1 , M T Reetz
Affiliations

Solid-phase enzymatic synthesis of oligonucleotides

C Schmitz et al. Org Lett. .

Abstract

[formula: see text] The controlled and selective synthesis of oligonucleotides on the solid phase is possible under mild aqueous conditions using the enzyme T4 RNA ligase, the resins being tentagel or kieselguhr/polydimethylacrylamide.

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