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. 2000 Feb;47(1):37-41.
doi: 10.1046/j.1439-0442.2000.00260.x.

Pharmacokinetics of miocamycin following intravenous administration to cattle

N J Litterio  1 , M R Rubio, E A Formentini, D C Díaz, E J Picco, T Encinas, J C Boggio
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Pharmacokinetics of miocamycin following intravenous administration to cattle

N J Litterio et al. J Vet Med A Physiol Pathol Clin Med. 2000 Feb.

Abstract

The plasma pharmacokinetics for a single intravenous dose (10 mg/kg body weight) of miocamycin (a 16-membered macrolide drug) was investigated in Holando Argentino cattle (n = 5). Blood drug concentrations were determined by a microbiological method and data were best-fitted to a two-compartment open model. The pharmacokinetic profile consisted of a short distribution phase (t1/2 alpha = 7.41 +/- 0.53 min), followed by an extended terminal elimination phase (t1/2 beta = 2.49 +/- 0.23 h). The volume of distribution at steady-state was large (2.13 +/- 0.17 l/kg), suggesting extensive tissue distribution, the clearance value was 0.60 +/- 0.03 l/h.

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