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. 2000 Jun 6;97(12):6242-4.
doi: 10.1073/pnas.97.12.6242.

Glioblastoma multiforme: the terminator

E C Holland  1
Affiliations

Glioblastoma multiforme: the terminator

E C Holland. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Secondary structures of Scherer demonstrating migration of glioma cells through normal brain structures. (A) Glioma cells surrounding blood vessels (perivascular satellitosis) (arrow). (B) Perineuronal satellitosis (arrow). (C) Collection of cells below pial surface (subpial spread) (arrow). (D) Intrafascicular spread of tumor cells through the corona radiata.
Figure 2
Figure 2
MRI scans of a patient with a right temporal GBM illustrating the spread of the disease. (A) Presurgical scan, GBM (arrow) is surrounded with edema. (B) Scan after surgery and radiation therapy showing “gross total resection” and clear resection cavity, and (C) six months later, showing recurrence not only at the resection margin (arrow) but a second focus of GBM across the Sylvian fissure in the frontal lobe (arrow). (D) Postresection scans of both recurrent tumors. (E) Scan 3 months later, showing the tumor recurring at the resection margin and crossing the corpus callosum to the other hemisphere (arrow).
Figure 3
Figure 3
Kaplan–Meier survival plots for patients diagnosed with GBM. Curves A, B, and C are historical data from Jelsma and Bucy (8) published in 1967 before the availability of MRI scans: biopsy only (A), extensive resection (undefined) (B), and extensive resection followed by radiation therapy (C). Curve D is current data from the M. D. Anderson Cancer Center on patients with >95% resection (by volumetric MRI measurements) followed by both radiation therapy and chemotherapy. Although there are essentially no long-term survivors, removal of tumor mass clearly increases longevity.
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References

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