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. 2000 Mar;19(3):593-601.
doi: 10.1080/15257770008035010.

Synthesis of oligodeoxyribonucleotide bearing 2'-S-alkyl residue and its effect on the duplex stability

H Ozaki  1 , Y Sato, S Azuma, H Sawai
Affiliations

Synthesis of oligodeoxyribonucleotide bearing 2'-S-alkyl residue and its effect on the duplex stability

H Ozaki et al. Nucleosides Nucleotides Nucleic Acids. 2000 Mar.

Abstract

2'-Deoxy-2'-S-hexyluridine derivative was synthesized from 2,2'-anhydrouridine and 1-hexanethiol and incorporated into an oligodeoxyribonucleotide. The thermal stability of the duplexes formed by the 2'-S-hexyl modified ODN with either the complementary DNA or RNA strand was decreased compared to the unmodified counterparts.

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