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. 2000 May;10(1):1-9.
doi: 10.1002/(sici)1097-0193(200005)10:1<1::aid-hbm10>3.0.co;2-o.

Six-month test-retest reliability of MRI-defined PET measures of regional cerebral glucose metabolic rate in selected subcortical structures

S M Schaefer  1 , H C Abercrombie, K A Lindgren, C L Larson, R T Ward, T R Oakes, J E Holden, S B Perlman, P A Turski, R J Davidson
Affiliations

Six-month test-retest reliability of MRI-defined PET measures of regional cerebral glucose metabolic rate in selected subcortical structures

S M Schaefer et al. Hum Brain Mapp. 2000 May.

Abstract

Test-retest reliability of resting regional cerebral metabolic rate of glucose (rCMR) was examined in selected subcortical structures: the amygdala, hippocampus, thalamus, and anterior caudate nucleus. Findings from previous studies examining reliability of rCMR suggest that rCMR in small subcortical structures may be more variable than in larger cortical regions. We chose to study these subcortical regions because of their particular interest to our laboratory in its investigations of the neurocircuitry of emotion and depression. Twelve normal subjects (seven female, mean age = 32.42 years, range 21-48 years) underwent two FDG-PET scans separated by approximately 6 months (mean = 25 weeks, range 17-35 weeks). A region-of-interest approach with PET-MRI coregistration was used for analysis of rCMR reliability. Good test-retest reliability was found in the left amygdala, right and left hippocampus, right and left thalamus, and right and left anterior caudate nucleus. However, rCMR in the right amygdala did not show good test-retest reliability. The implications of these data and their import for studies that include a repeat-test design are considered.

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Figures

Figure 1
Figure 1
PET‐MRI coregistration and ROI delineation. This figure presents representative image planes, four coronal sections, for one participant. From top to bottom, example right and left ROI of the anterior caudate nucleus, the amygdala, the hippocampus, and the thalamus. The top images correspond to an anterior plane and each successive image corresponds to an increasingly posterior plane. PET image planes are presented to the right of their corresponding co‐registered [using AIR; Woods et al., 1993] MRI plane.
Figure 2
Figure 2
Test–retest correlations. This figure presents scatterplots between the normalized rCMR from scans 1 (test) and 2 (retest) in the left and right anterior caudate nucleus, amygdala, hippocampus, and thalamus.
See this image and copyright information in PMC

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