Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Jul 1;144(1):282-7.
doi: 10.1084/jem.144.1.282.

Association between Ia antigens and the Fc receptors of certain T lymphocytes

H B Dickler, R D Arbeit, P A Henkart, D H Sachs

Association between Ia antigens and the Fc receptors of certain T lymphocytes

H B Dickler et al. J Exp Med. .

Abstract

The Fc receptors of thymic and splenic T lymphocytes were detected using indirect immunofluorescence and soluble antigen-antibody complexes. 10-20% of thymocytes and 40-50% of Thy-1-positive splenic lymphocytes bound antigen-complexed Ig. The binding to thymocytes was partially inhibited (45-74%) by antibodies against antigens determined by the I region of the H-2 complex, but not by antibodies against K- or D-region antigens or Thy-1 antigen. The inhibition did not require the Fc portion of the inhibiting antibody. These results provide evidence that Ia antigens and the Fc receptors of some T lymphocytes are associated, and that the populations of T cells which bear these moieties at least partially overlap.

PubMed Disclaimer

References

    1. J Immunol. 1975 Oct;115(4):1159-65 - PubMed
    1. Nature. 1975 Sep 18;257(5523):230-1 - PubMed
    1. J Exp Med. 1975 May 1;141(5):1201-9 - PubMed
    1. Arch Biochem Biophys. 1960 Aug;89:230-44 - PubMed
    1. Int Arch Allergy Appl Immunol. 1976;50(3):309-21 - PubMed