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. 1976 Jul 1;144(1):293-7.
doi: 10.1084/jem.144.1.293.

Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance

J C Cambier, J R Kettman, E S Vitetta, J W Uhr

Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance

J C Cambier et al. J Exp Med. .

Abstract

The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C' and the helper T cells with anti-Ly-2.2 and C'. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed.

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References

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