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. 2000 Jun;22(3):354-65.
doi: 10.1097/00007691-200006000-00019.

Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods

R Jelliffe  1 , A Schumitzky, M Van Guilder
Affiliations

Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods

R Jelliffe et al. Ther Drug Monit. 2000 Jun.

Abstract

As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects.

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