Molecular determinants of presynaptic active zones
- PMID: 10851173
- DOI: 10.1016/s0959-4388(00)00093-3
Molecular determinants of presynaptic active zones
Abstract
The presynaptic cytoskeletal matrix (cytomatrix) assembled at active zones has been implicated in defining neurotransmitter release sites. Munc13, Rim, Bassoon and Piccolo/Aczonin are recently identified presynaptic cytomatrix proteins. These multidomain proteins are thought to organize the exocytotic and endocytotic machinery precisely at active zones.
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