Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Jun 13;54(11):2173-6.
doi: 10.1212/wnl.54.11.2173.

Autosomal dominant partial epilepsy with auditory features: defining the phenotype

M R Winawer  1 , R Ottman, W A Hauser, T A Pedley
Affiliations

Autosomal dominant partial epilepsy with auditory features: defining the phenotype

M R Winawer et al. Neurology. .

Abstract

The authors previously reported linkage to chromosome 10q22-24 for autosomal dominant partial epilepsy with auditory features. This study describes seizure semiology in the original linkage family in further detail. Auditory hallucinations were most common, but other sensory symptoms (visual, olfactory, vertiginous, and cephalic) were also reported. Autonomic, psychic, and motor symptoms were less common. The clinical semiology points to a lateral temporal seizure origin. Auditory hallucinations, the most striking clinical feature, are useful for identifying new families with this synome.

PubMed Disclaimer

References

    1. Ottman R, Risch N, Hauser WA, et al. Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet. 1995;10:56–60. - PMC - PubMed
    1. Gil-Nagel A, Risinger M. Ictal semiology in hippocampal versus extrahippocampal temporal lobe epilepsy. Brain. 1997;120:183–192. - PubMed
    1. Palmini A, Gloor P. The localizing value of auras in partial seizures: a prospective and retrospective study. Neurology. 1992;42:801–808. - PubMed
    1. Penfield W, Kristiansen K. Epileptic seizure patterns: a study of the localizing value of initial phenomena in focal cortical seizures. Charles C Thomas; Springfield, IL: 1951.
    1. Poza JJ, Sáenz A, Martínez-Gil A, et al. Autosomal dominant lateral temporal epilepsy: clinical and genetic study of a large Basque pedigree linked to chromosome 10q. Ann Neurol. 1999;45:182–188. - PubMed

Publication types