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Review
. 1999;193(1):85-99.

[MUC genes: a superfamily of genes? Towards a functional classification of human apomucins]

[Article in French]
N Porchet  1 , M P Buisine, J L Desseyn, N Moniaux, S Nollet, P Degand, P Pigny, I Van Seuningen, A Laine, J P Aubert
Affiliations
  • PMID: 10851560
Review

[MUC genes: a superfamily of genes? Towards a functional classification of human apomucins]

[Article in French]
N Porchet et al. J Soc Biol. 1999.

Abstract

The MUC genes encode epithelial mucins. Eight different human genes have been well characterized, and two others identified more recently. Among them, a family of four genes, expressed in the respiratory and digestive tracts, is clustered to chromosome 11p15.5; and these genes encode gel-forming mucins which are structurally related to the superfamily of cystine-knot growth factors. A second group is composed of three independent genes encoding various isoforms of mucins including membrane-bound mucins associated to carcinomas. In this second group, MUC3 and MUC4 encode large apomucins containing EGF-like domains.

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