Comparative Study
doi: 10.1016/0014-2999(76)90045-5.
Tryptophan hydroxylase in discrete brain nuclei: comparison of activity in vitro and in vivo
- PMID: 1085253
- DOI: 10.1016/0014-2999(76)90045-5
Item in Clipboard
Comparative Study
Tryptophan hydroxylase in discrete brain nuclei: comparison of activity in vitro and in vivo
Eur J Pharmacol.
1976 Jun.
Abstract
The increase of 5-hydroxytryptophan after treatment with the decarboxylase inhibitor Ro 4/4602 was 30 times greater in the raphe nuclei (which contain serotonergic cell bodies) than the hippocampus or caudate (which contain serotonergic terminals). Pretreatment with chlorimipramine reduced the 5-hydroxytryptophan accumulation in the median but not dorsal raphe. The large amount of tryptophan hydroxylase in cell bodies appears to be active in vivo. The serotonin rapidly turning over there may have a functional role.
Similar articles
-
Septal tryptophan-5-hydroxylase: divergent response to raphe lesions and parachlorophenylalanine.Science. 1974 Mar 1;183(4127):869-71. doi: 10.1126/science.183.4127.869. Science. 1974. PMID: 4272645
-
Demonstration, characterization, and assay procedure of tryptophan hydroxylase in rat brain.Anal Biochem. 1966 Apr;15(1):53-64. doi: 10.1016/0003-2697(66)90247-8. Anal Biochem. 1966. PMID: 5297516 No abstract available.
-
Daily variations of various parameters of serotonin metabolism in the rat brain. I. Circadian variations of tryptophan-5-hydroxylase in the raphe nuclei and the striatum.Brain Res. 1977 Mar 4;123(1):125-36. doi: 10.1016/0006-8993(77)90647-3. Brain Res. 1977. PMID: 843910
-
Tryptophan hydroxylase of the central nervous system: effect of intraventricular 5,6- and 5,7-dihydroxytryptamine.Adv Biochem Psychopharmacol. 1974;10:93-101. Adv Biochem Psychopharmacol. 1974. PMID: 4603031 Review. No abstract available.
-
Glucocorticoid regulation of the serotonergic system of the brain.Adv Biochem Psychopharmacol. 1976;15:251-65. Adv Biochem Psychopharmacol. 1976. PMID: 15419 Review.
Cited by
-
Ontogenetic studies on tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes: effect of thyroid hormones.Neurochem Res. 1985 May;10(5):579-89. doi: 10.1007/BF00964397. Neurochem Res. 1985. PMID: 4010873
-
Serotonin turnover rate in raphe and cortex of mice infected with Venezuelan equine encephalomyelitis virus.J Neurosci Res. 1987;17(4):428-34. doi: 10.1002/jnr.490170415. J Neurosci Res. 1987. PMID: 2442407 Free PMC article.
-
Long-term regulation of serotonergic activity in the rat brain via activation of protein kinase A.EMBO J. 1993 Mar;12(3):903-10. doi: 10.1002/j.1460-2075.1993.tb05731.x. EMBO J. 1993. PMID: 8384555 Free PMC article.
-
Simultaneous quantification of dopamine, 5-hydroxytryptamine and four metabolically related compounds by means of reversed-phase high-performance liquid chromatography with electrochemical detection.J Chromatogr. 1981 Oct 9;225(2):347-57. doi: 10.1016/s0378-4347(00)80283-2. J Chromatogr. 1981. PMID: 7298770 Free PMC article.
-
Daily variations in in vivo tryptophan hydroxylation and in the contents of serotonin and 5-hydroxyindoleacetic acid in discrete brain areas of the rat.J Neural Transm Gen Sect. 1993;92(2-3):137-50. doi: 10.1007/BF01244873. J Neural Transm Gen Sect. 1993. PMID: 7690229
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
