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. 1976 May 22;1(21):777-9.

Methotrexate megadosage followed by folate rescue. I. A study in clearance patterns

S Salasoo, M G Irving, R Lam-Po0Tang, D O'Gorman-Hughes, A Freedman
  • PMID: 1085404

Methotrexate megadosage followed by folate rescue. I. A study in clearance patterns

S Salasoo et al. Med J Aust. .

Abstract

Plasma clearance rates of methotrexate (MTX) have been determined in five patients given an infusion of 3,000 mg of MTX over six hours, followed by folate rescue 24 hours after the commencement of infusion. Results presented indicate that maintenance of high MTX concentrations and potential toxicity could not be related to age, body weight or surface area.

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