Methotrexate megadose followed by folate rescue. II. Clearance patterns in patients receiving sequential megadose infusions
- PMID: 1085406
Item in Clipboard
Methotrexate megadose followed by folate rescue. II. Clearance patterns in patients receiving sequential megadose infusions
Med J Aust.
.
Abstract
In some patients receiving megadose infusions of methotrexate (MTX), the rate of drug clearance decreases with each subsequent infusion. This can be modified by administration of fluids as outlined in the Recommended Protocol. Monitoring of each treatment is needed to assess requirements of fluids since these cannot be adequately predicted from data of previous infusions.
Similar articles
-
High-dose methotrexate therapy of childhood acute lymphoblastic leukemia: lack of relation between serum methotrexate concentration and creatinine clearance.Pediatr Blood Cancer. 2004 Jul;43(1):17-22. doi: 10.1002/pbc.20032. Pediatr Blood Cancer. 2004. PMID: 15170885 Clinical Trial.
-
Methotrexate megadosage followed by folate rescue. I. A study in clearance patterns.Med J Aust. 1976 May 22;1(21):777-9. Med J Aust. 1976. PMID: 1085404
-
[High dose methotrexate with leucovorin rescue in the treatment of malignant lymphoma].Gan To Kagaku Ryoho. 1982 Jul;9(6):1068-73. Gan To Kagaku Ryoho. 1982. PMID: 6985194 Japanese.
-
Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates.NCI Monogr. 1987;(5):17-26. NCI Monogr. 1987. PMID: 2448654 Review.
-
Antineoplastic agents: high-dose methotrexate and citrovorum factor rescue.Ther Drug Monit. 1980;2(2):177-85. Ther Drug Monit. 1980. PMID: 6762711 Review.
Cited by
-
Effect of urine pH and flow on renal clearance of methotrexate.Eur J Clin Pharmacol. 1981;19(6):453-6. doi: 10.1007/BF00548590. Eur J Clin Pharmacol. 1981. PMID: 7250179
-
Clinical pharmacokinetics of methotrexate.Clin Pharmacokinet. 1978 Jan-Feb;3(1):1-13. doi: 10.2165/00003088-197803010-00001. Clin Pharmacokinet. 1978. PMID: 346283 Review. No abstract available.
-
Pharmacokinetics of high-dose methotrexate treatment in children.Eur J Clin Pharmacol. 1978 Nov 16;14(2):143-7. doi: 10.1007/BF00607446. Eur J Clin Pharmacol. 1978. PMID: 720376
-
Nonlinear renal elimination kinetics of methotrexate due to saturation of renal tubular reabsorption.Eur J Clin Pharmacol. 1984;26(1):121-4. doi: 10.1007/BF00546719. Eur J Clin Pharmacol. 1984. PMID: 6714284