Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 May 29;1(22):826-8.

Methotrexate megadose followed by folate rescue. II. Clearance patterns in patients receiving sequential megadose infusions

S Salasoo, M G Irving, A Freedman
  • PMID: 1085406

Methotrexate megadose followed by folate rescue. II. Clearance patterns in patients receiving sequential megadose infusions

S Salasoo et al. Med J Aust. .

Abstract

In some patients receiving megadose infusions of methotrexate (MTX), the rate of drug clearance decreases with each subsequent infusion. This can be modified by administration of fluids as outlined in the Recommended Protocol. Monitoring of each treatment is needed to assess requirements of fluids since these cannot be adequately predicted from data of previous infusions.

PubMed Disclaimer