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. 1976 Aug 30;12(2):67-71.
doi: 10.1007/BF01731551.

Phospholipids bound to acidic nuclear proteins in human B and T lymphocytes

F A Manzoli, L Cocco, A Facchini, A M Casali, N M Maraldi, C E Grossi

Phospholipids bound to acidic nuclear proteins in human B and T lymphocytes

F A Manzoli et al. Mol Cell Biochem. .

Abstract

Chromatin fractions (DNA, histones and non-histone chromosomal proteins NHCP) have been isolated from human peripheral B and T lymphocytes using different methods and analyzed in order to identify their lipid content. While DNA and histone fractions do not reveal the presence of lipids, a 2% of phospholipids is present in the NHCP fraction. The phospholipids associated with NHCP present a constant relative ratio among sphingomyelin, phosphatidyl-choline and phosphatidyl-ethanolamine both in B and T lymphocytes, whichever are the extraction procedures employed. These findings are related to the possible dereprssive role of phospholipids on DNA-dependent RNA synthesis.

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References

    1. Arch Oral Biol. 1968 Jun;13(6):705-8 - PubMed
    1. J Mol Biol. 1972 Jun 20;67(2):231-46 - PubMed
    1. FEBS Lett. 1974 Jan 15;38(3):247-58 - PubMed
    1. Nature. 1970 Oct 10;228(5267):132-4 - PubMed
    1. Clin Exp Immunol. 1969 Apr;4(4):457-72 - PubMed