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Comparative Study
. 2000 Jun;150(2):295-8.
doi: 10.1016/s0021-9150(99)00379-2.

A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression

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Comparative Study

A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression

T Suehiro et al. Atherosclerosis. 2000 Jun.

Abstract

Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (-108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the -108T allele than in the -108C allele. The serum PON1 concentrations in 132 normal subjects were as follows: -108CC>-108CT and>-108TT genotypes. The polymorphism upstream from the PON1 gene is associated with transcription of the PON1 gene and the serum PON1 concentration.

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