Leukemia-inhibitory factor-neuroimmune modulator of endocrine function
- PMID: 10857556
- DOI: 10.1210/edrv.21.3.0400
Leukemia-inhibitory factor-neuroimmune modulator of endocrine function
Abstract
Leukemia-inhibitory factor (LIF) is a pleiotropic cytokine expressed by multiple tissue types. The LIF receptor shares a common gp130 receptor subunit with the IL-6 cytokine superfamily. LIF signaling is mediated mainly by JAK-STAT (janus-kinase-signal transducer and activator of transcription) pathways and is abrogated by the SOCS (suppressor-of cytokine signaling) and PIAS (protein inhibitors of activated STAT) proteins. In addition to classic hematopoietic and neuronal actions, LIF plays a critical role in several endocrine functions including the utero-placental unit, the hypothalamo-pituitary-adrenal axis, bone cell metabolism, energy homeostasis, and hormonally responsive tumors. This paper reviews recent advances in our understanding of molecular mechanisms regulating LIF expression and action and also provides a systemic overview of LIF-mediated endocrine regulation. Local and systemic LIF serve to integrate multiple developmental and functional cell signals, culminating in maintaining appropriate hormonal and metabolic homeostasis. LIF thus functions as a critical molecular interface between the neuroimmune and endocrine systems.
Similar articles
-
[Function, molecular structure and gene expression regulation of receptor for D-factor/LIF].Nihon Rinsho. 1992 Aug;50(8):1956-61. Nihon Rinsho. 1992. PMID: 1433987 Review. Japanese.
-
[Leukemia inhibitory factor and its physiological functions during embryo development and blastocyst implantation].Sheng Li Ke Xue Jin Zhan. 1997 Jul;28(3):240-2. Sheng Li Ke Xue Jin Zhan. 1997. PMID: 11038733 Review. Chinese. No abstract available.
-
Role of leukemia inhibitory factor during mammalian development.Eur Cytokine Netw. 1996 Dec;7(4):699-712. Eur Cytokine Netw. 1996. PMID: 9010672 Review.
-
Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ cells.Endocrinology. 1998 Apr;139(4):1883-90. doi: 10.1210/endo.139.4.5871. Endocrinology. 1998. PMID: 9528974
-
Pituitary corticotroph SOCS-3: novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion.Mol Endocrinol. 1998 Jul;12(7):954-61. doi: 10.1210/mend.12.7.0140. Mol Endocrinol. 1998. PMID: 9658400
Cited by
-
Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection.Viral Immunol. 2005;18(1):41-78. doi: 10.1089/vim.2005.18.41. Viral Immunol. 2005. PMID: 15802953 Free PMC article. Review.
-
Unveiling the Role of the Proton Gateway, Uncoupling Proteins (UCPs), in Cancer Cachexia.Cancers (Basel). 2023 Feb 23;15(5):1407. doi: 10.3390/cancers15051407. Cancers (Basel). 2023. PMID: 36900198 Free PMC article. Review.
-
Analyses of porcine public SNPs in coding-gene regions by re-sequencing and phenotypic association studies.Mol Biol Rep. 2011 Aug;38(6):3805-20. doi: 10.1007/s11033-010-0496-1. Epub 2010 Nov 24. Mol Biol Rep. 2011. PMID: 21107721
-
Modulation of immune responses in stress by Yoga.Int J Yoga. 2008 Jul;1(2):45-55. doi: 10.4103/0973-6131.43541. Int J Yoga. 2008. PMID: 21829284 Free PMC article.
-
Regulation and function of trefoil factor family 3 expression in the biliary tree.Am J Pathol. 2004 Dec;165(6):1907-20. doi: 10.1016/S0002-9440(10)63243-9. Am J Pathol. 2004. PMID: 15579435 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous