Arthritogenicity of Mycobacterium smegmatis subfractions, related to different oil vehicle and different composition
- PMID: 1085757
- DOI: 10.1159/000231620
Arthritogenicity of Mycobacterium smegmatis subfractions, related to different oil vehicle and different composition
Abstract
Arthrigenicity of Mycobacterium smegmatis subfractions appeared to be remarkably potentiated in oil vehicles such as squalane or mineral oil, while water-in-oil emulsions containing Arlacel A appeared to decrease or suppress their arthritogenicity. It seems that Arlacel A can exert a suppressive effect on the arthritogenicity of the subfractions. Poly I:C and acetylated wax D potentiated the arthritogenicity of lysozyme-solubilized product, while cord factor was unable to do so. When given together with either cell membrane fraction or cell envelope, the lysozyme-solubilized product produced much more severe disease than that of lysozyme-solubilized product alone. Cell walls lost much of their arthritogenicity when mixed with lysozyme-solubilized product.
Similar articles
-
Arthritis-inducing ability of a synthetic adjuvant, N-acetylmuramyl peptides, and bacterial disaccharide peptides related to different oil vehicles and their composition.Infect Immun. 1980 Jul;29(1):70-5. doi: 10.1128/iai.29.1.70-75.1980. Infect Immun. 1980. PMID: 7399708 Free PMC article.
-
Arthritogenicity of wax D from various mycobacteria related to oil vehicle composition and to the combination with poly I:C, cord factor and acetylated wax D.Int Arch Allergy Appl Immunol. 1977;53(4):357-65. doi: 10.1159/000231772. Int Arch Allergy Appl Immunol. 1977. PMID: 852904
-
Preparation of various fractions from Mycobacterium smegmatis, their arthritogenicity and their preventive effect on adjuvant disease.Int Arch Allergy Appl Immunol. 1976;51(4):451-61. doi: 10.1159/000231619. Int Arch Allergy Appl Immunol. 1976. PMID: 1085756
-
Squalene and squalane emulsions as adjuvants.Methods. 1999 Sep;19(1):87-93. doi: 10.1006/meth.1999.0832. Methods. 1999. PMID: 10525443 Review.
-
Assessment of the morphology and significance of the lymph nodal and hepatic lesions produced in rats by the feeding of certain mineral oils and waxes. Proceedings of a pathology workshop held at the Fraunhofer Institute of Toxicology and Aerosol Research Hannover, Germany, May 7-9, 2001.Exp Toxicol Pathol. 2001 Sep;53(4):247-55. doi: 10.1078/0940-2993-00198. Exp Toxicol Pathol. 2001. PMID: 11665848 Review.
Cited by
-
Synergistic effect of polyriboinosinic acid:polyribocytidylic acid and either bacterial peptidoglycans or synthetic N-acetylmuramyl peptides on production of adjuvant-induced arthritis in rats.Infect Immun. 1979 Nov;26(2):690-7. doi: 10.1128/iai.26.2.690-697.1979. Infect Immun. 1979. PMID: 546792 Free PMC article.
-
Susceptibility to adjuvant-induced arthritis among germfree, specific-pathogen-free, and conventional rats.Infect Immun. 1979 Dec;26(3):791-4. doi: 10.1128/iai.26.3.791-794.1979. Infect Immun. 1979. PMID: 160888 Free PMC article.
-
Effect of oil composition on both adjuvant-induced arthritis and delayed hypersensitivity to purified protein derivative and peptidoglycans in various rat strains.Infect Immun. 1977 Aug;17(2):244-9. doi: 10.1128/iai.17.2.244-249.1977. Infect Immun. 1977. PMID: 892904 Free PMC article.
-
Arthritis-inducing ability of a synthetic adjuvant, N-acetylmuramyl peptides, and bacterial disaccharide peptides related to different oil vehicles and their composition.Infect Immun. 1980 Jul;29(1):70-5. doi: 10.1128/iai.29.1.70-75.1980. Infect Immun. 1980. PMID: 7399708 Free PMC article.