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Review
. 2000 Jun;12(3):346-53.
doi: 10.1016/s0952-7915(00)00098-4.

Development and function of B-1 cells

K Hayakawa  1 , R R Hardy
Affiliations
Review

Development and function of B-1 cells

K Hayakawa et al. Curr Opin Immunol. 2000 Jun.

Abstract

Results from immunoglobulin-transgenic mice and BCR-mutant mice have been widely interpreted in recent years as supporting a simple 'activation' model for the origin of CD5+/B-1 B cells. However cell transfer experiments over 10 years ago and recent work investigating pre-BCR signaling suggest striking differences between B cell development in fetal liver and adult bone marrow, lending support for a 'lineage' model that we favor. Recent progress has been made relating to the development and function of the CD5+/B-1 B cell subpopulation in mice; the data can be viewed in the context of the generation of this subpopulation by a distinctive fetal B cell developmental process.

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