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Case Reports
. 2000 May 20;29(18):992-3.

[Extra-pyramidal syndrome induced by donepezil]

[Article in French]
D Carcenac  1 , C Martin-Hunyadi, M Kiesmann, C Demuynck-Roegel, M Alt, F Kuntzmann
Affiliations
  • PMID: 10862247
Case Reports

[Extra-pyramidal syndrome induced by donepezil]

[Article in French]
D Carcenac et al. Presse Med. .

Abstract

Background: The cholinergic hypothesis of Alzheimer's disease is the basis of a new class of drugs: acetylcholinesterase inhibitors. These drugs have few side effects, mainly digestive disorders.

Case reports: Extra-pyramidal side effects with severe gait disorders were observed in 3 patients with Alzheimer's dementia treated with donepezil. This drug was associated with paroxetine or a neuroleptic. In 2 of the 3 cases, the extra-pyramidal effects disappeared when donepezil was discontinued.

Discussion: Extra-pyramidal syndromes in elderly subjects with cognitive impairment are difficult to interpret. The possible causes include interactions between acetylcholinesterase inhibitors, neuroleptics and serotonine reuptake inhibitors and Lewy body dementia.

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