Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Jun;105(12):1663-8.
doi: 10.1172/JCI10413.

Marrow stromal stem cells

P Bianco  1 , P Gehron Robey
Affiliations
Review

Marrow stromal stem cells

P Bianco et al. J Clin Invest. 2000 Jun.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
During development, precursor cells become committed to skeletogenesis upon induction of the critical osteogenic transcription factor, cbfa1. The initial phenotype expressed by these cells is that of fully mature osteoblasts. Subsequently, when a threshold amount of bone has been formed, these cells form the primitive bone marrow stroma that serves as the bed upon which hematopoiesis occurs. At some point during the postnatal period, when hematopoiesis is sufficient, these same cells change phenotype yet again to become marrow adipocytes. Cells of these three phenotypes (osteoblastic, myelosupportive, and adipocytic) form a continuous network throughout the bone–bone marrow organ and maintain expression of cbfa1. These differentiated cells are able to shift from one phenotype to another, depending on the metabolic status of the organism.
See this image and copyright information in PMC

References

    1. Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic transplants of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968;6:230–247. - PubMed
    1. Friedenstein AJ, et al. Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol. 1974;2:83–92. - PubMed
    1. Owen M. Marrow stromal stem cells. J Cell Sci Suppl. 1988;10:63–76. - PubMed
    1. Friedenstein AJ, Shapiro-Piatetzky II, Petrakova KV. Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol. 1966;16:381–390. - PubMed
    1. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. 1998;238:265–272. - PubMed

Publication types

MeSH terms

Grants and funding