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Comment
. 2000 Jun;105(12):1679-81.
doi: 10.1172/JCI10375.

The future of allogeneic hematopoietic stem cell transplantation: minimizing pain, maximizing gain

M T Little  1 , R Storb
Affiliations
Comment

The future of allogeneic hematopoietic stem cell transplantation: minimizing pain, maximizing gain

M T Little et al. J Clin Invest. 2000 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Schematic illustration of nonmyeloablative HSCT-induced mixed donor-host chimerism. Successful transplantation generally requires some level of host immunosuppression, except in cases of T-cell deficiency. This has often involved harsh TBI, but there is great interest in reducing the dosage to low, easily tolerated levels, such as the 200 cGy shown here, or even replacing this step entirely with other forms of conditioning. This process leads first to a state of mixed chimerism, in which both donor and recipient cells are detectable in the subject’s lymphoid and myeloid compartments and thymus. To correct recessive genetic diseases, this state of mixed chimerism may suffice, whereas other conditions, such as malignancy and autoimmune disease, may require the complete replacement of host cells with donor cells. Such a state of all-donor chimerism can be initiated either in a spontaneous episode of graft-versus-host disease or through an infusion of donor lymphocytes.
See this image and copyright information in PMC

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References

    1. Fuchimoto Y, et al. Mixed chimerism and tolerance without whole body irradiation in a large animal model. J Clin Invest. 2000;105:1779–1789. - PMC - PubMed
    1. Storb R, et al. Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation. Blood. 1997;89:3048–3054. - PubMed
    1. McSweeney PA, et al. Outpatient PBSC allografts using immunosuppression with low-dose TBI before, and cyclosporine (CSP) and mycophenolate mofetil (MMF) after transplant. Blood. 1999;94(Suppl. 1):519a. (Abstr.)
    1. Storb R, et al. Stable mixed chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant. Blood. 1999;94:2523–2529. - PubMed
    1. Storb R, et al. Stable mixed hematopoietic chimerism in dog leukocyte antigen-identical littermate dogs given lymph node irradiation before and pharmacologic immunosuppression after marrow transplantation. Blood. 1999;94:1131–1136. - PubMed

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