Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Jul;69(1):121-3.
doi: 10.1136/jnnp.69.1.121.

Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis

R Giess  1 , M Naumann, E Werner, R Riemann, M Beck, I Puls, C Reiners, K V Toyka
Affiliations

Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis

R Giess et al. J Neurol Neurosurg Psychiatry. 2000 Jul.

Abstract

Sialorrhoea is a socially disabling problem in bulbar amyotrophic lateral sclerosis (ALS). Botulinum toxin A (BoNT/A) was injected into the salivary glands in five patients with bulbar ALS and sialorrhoea. The effect of BoNT/A was measured by the number of paper handkerchiefs used each day and by salivary gland scintigraphy. BoNT/A ameliorated sialorrhoea and quality of life without major adverse effects. BoNT/A may be a relatively safe and effective treatment for sialorrhoea in selected patients.

PubMed Disclaimer

Comment in

Substances