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. 2000 Jun 5;10(11):1207-10.
doi: 10.1016/s0960-894x(00)00188-8.

9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis

A K Bakkestuen  1 , L L Gundersen, G Langli, F Liu, J M Nolsøe
Affiliations

9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis

A K Bakkestuen et al. Bioorg Med Chem Lett. .

Abstract

9-Benzylpurines with a variety of substituents in the 2-, 6- and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl-, trans-styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity.

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