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Review
. 2000;17(3):209-15.
doi: 10.1159/000018853.

What's new with tumor markers for colorectal cancer?

R M Pokorny  1 , L Hunt, S Galandiuk
Affiliations
Review

What's new with tumor markers for colorectal cancer?

R M Pokorny et al. Dig Surg. 2000.

Abstract

Background/aims: Many tumor markers have been utilized in the follow-up care of colorectal cancer patients. No marker, however, has proven reliably accurate in detecting recurrent disease.

Methods: The strengths and weaknesses of currently available tumor markers are reviewed, with attention to related cost and efficacy.

Results: Tumor antigens, enzymes, and genetic markers have been used as tumor markers. CEA and CA 19.9 are the most widely utilized; however, genetic markers are the most promising for the future.

Conclusions: Currently available markers have significant limitations. Development of genetic markers may greatly enhance our ability to predict prognosis and the need for adjuvant therapy. Marker-guided therapy may play an increasing role in this disease.

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