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Review
. 2000 Apr;20(3):223-5.
doi: 10.1016/s0741-8329(99)00085-3.

Safety and tolerability of gamma-hydroxybutyric acid in the treatment of alcohol-dependent patients

F Beghè  1 , M T Carpanini
Affiliations
Review

Safety and tolerability of gamma-hydroxybutyric acid in the treatment of alcohol-dependent patients

F Beghè et al. Alcohol. 2000 Apr.

Abstract

Gamma-hydroxybutyric acid (GHB) has been in clinical use in Italy since 1991 for treatment of alcohol dependence. Results of phase III and phase IV studies have shown that the drug is effective and well tolerated in the treatment of alcohol withdrawal syndrome and in reducing alcohol consumption and alcohol craving. Pharmacosurveillance indicates that abuse of gamma-hydroxybutyric acid is a limited phenomenon in clinical settings when the drug is dispensed under strict medical surveillance and entrusted to a referring familiar member of the patient.

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