Inhibition-mediating dopamine receptors and the control of intracranial reward
- PMID: 108718
- DOI: 10.1007/BF00426808
Inhibition-mediating dopamine receptors and the control of intracranial reward
Abstract
A receptor selective agonist and antagonist of inhibition-mediating dopamine receptors (type II receptors) produced significant and dose-related alterations in bar-pressing for intracranial reward. Receptor inhibition by piribedil increased responding for reward while receptor activation by 3,4-dihydroxyphenylamino-2-imidazoline reduced responding. Inhibition-mediating receptors may therefore play a role opposite to classic excitation-mediating receptors in controlling reward.
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