Review
doi: 10.1016/s0167-5699(00)01636-4.
Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40
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- PMID: 10871874
- DOI: 10.1016/s0167-5699(00)01636-4
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Review
Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40
Immunol Today.
2000 Jul.
Abstract
Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.
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