Review
doi: 10.1016/s0167-5699(00)01653-4.
The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis
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- PMID: 10871877
- DOI: 10.1016/s0167-5699(00)01653-4
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Review
The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis
Immunol Today.
2000 Jul.
Abstract
The gastric H+/K+ ATPase is the causative autoantigen recognized by CD4+ T cells that mediate autoimmune gastritis. Pathogenic CD4+ T cells are regulated by CD25+CD4+ T cells. Here, it is proposed that waves of activation and migration of antigen presenting cells and CD4+ T cells to and from the target organ and draining lymph node result in tissue damage.
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