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Review
. 2000 Jul;21(7):348-54.
doi: 10.1016/s0167-5699(00)01653-4.

The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis

B H Toh  1 , J W Sentry, F Alderuccio
Affiliations
Review

The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis

B H Toh et al. Immunol Today. 2000 Jul.

Abstract

The gastric H+/K+ ATPase is the causative autoantigen recognized by CD4+ T cells that mediate autoimmune gastritis. Pathogenic CD4+ T cells are regulated by CD25+CD4+ T cells. Here, it is proposed that waves of activation and migration of antigen presenting cells and CD4+ T cells to and from the target organ and draining lymph node result in tissue damage.

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