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Case Reports
. 2000 Jun;136(6):707-10.
doi: 10.1001/archderm.136.6.707.

Regression of deeply infiltrating giant condyloma (Buschke-Löwenstein tumor) following long-term intralesional interferon alfa therapy

A Geusau  1 , G Heinz-Peer, B Volc-Platzer, G Stingl, R Kirnbauer
Affiliations
Case Reports

Regression of deeply infiltrating giant condyloma (Buschke-Löwenstein tumor) following long-term intralesional interferon alfa therapy

A Geusau et al. Arch Dermatol. 2000 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Left, Clinical presentation. A large, exophytic, cauliflowerlike perianal verrucous tumor is seen extending toward the perineum and scrotum. Right, Dramatic regression of the tumor is evident after 12 months of treatment.
Figure 2
Figure 2
Magnetic resonance imaging scans (short-time inversion recovery technique). Top, Before treatment, the tumor is seen infiltrating the internal obturator muscle, ischiorectal fossa, and perirectal space (arrows indicate the lateral tumor border). Bottom, After 12 months of treatment, the internal obturator muscle is again well defined (arrow).
Figure 3
Figure 3
Top, Pretreatment histologic section shows papillomatous tumor invading deeply into the underlying tissue, without penetration of the basement membrane (hematoxylin-eosin, original magnification ×200). Bottom, The epidermis is hyperplastic and well stratified with few mitoses or koilocytes (hematoxylin-eosin, original magnification ×400).
Figure 4
Figure 4
Histologic section of residual tissue after 12 months of treatment shows a bandlike mononuclear infiltrate in close approximation to and invading into the epidermis (hematoxylin-eosin, original magnification ×100).
See this image and copyright information in PMC

References

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    1. Zachariae H, Larsen PM, Sorgaard H. Recombinant interferon alpha -2a (Roferon-A) in a case of Buschke-Löwenstein giant condyloma. Dermatologica. 1988;177:175–179. - PubMed
    1. Tsambaos D, Monastirli A, Kapranos N, Georgiou S, Pasmatzi E, Berger H. Intralesional interferon alpha-2b therapy for Buschke-Loewenstein tumour. Acta Dermatol Venereol (Stockh) 1994;74:457–459. - PubMed

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