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Review
. 2000 Jun 15;10(12):R463-5.
doi: 10.1016/s0960-9822(00)00534-0.

Transcriptional control: imprinting insulation

A P Wolffe  1
Affiliations
Free article
Review

Transcriptional control: imprinting insulation

A P Wolffe. Curr Biol. .
Free article

Abstract

Recent studies on the transcriptional regulation of two linked, imprinted genes, Igf2 and H19, have provided evidence for a novel mechanism of epigenetic control. DNA methylation controls the activity of an insulator element located between the two linked genes by regulating the binding of the zinc-finger protein CTCF.

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