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. 1979 Mar 29;62(1):101-2.
doi: 10.1007/BF00426043.

Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration

G V Rebec, D S Segal

Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration

G V Rebec et al. Psychopharmacology (Berl). .

Abstract

Previous studies have demonstrated that long-term administration of d-amphetamine produces a progressive augmentation of behavior. In the present experiment, rats receiving repeated systemic injections responded to an intraventricular infusion of d-amphetamine with an augmented increase in locomotor activity. These results indicate that central mechanisms, rather than peripheral dispositional factors, subserve the enhanced behavioral response to repeated amphetamine administration.

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