Review
doi: 10.1254/jjp.82.15.
Molecular basis of spatio-temporal dynamics in inositol 1,4,5-trisphosphate-mediated Ca2+ signalling
Affiliations
- PMID: 10874583
- DOI: 10.1254/jjp.82.15
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Review
Molecular basis of spatio-temporal dynamics in inositol 1,4,5-trisphosphate-mediated Ca2+ signalling
Jpn J Pharmacol.
2000 Jan.
Free article
Abstract
Inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ signalling regulates many important cell functions, and the spatio-temporal dynamics of the Ca2+ signalling is a crucial factor for its versatility. The molecular mechanisms that control Ca2+ signalling are now being investigated, and I here describe the subtypes of IP3 receptors that have distinct functional properties and contribute to the diversity of Ca2+ signalling patterns. I also discuss the spatio-temporal dynamics of intracellular IP3 concentration, describing recent methodological advances in monitoring intracellular IP3 concentration. These findings highlight the potential importance of the spatio-temporal information of any signalling molecule.
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