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. 2000 Jul;2(7):407-14.
doi: 10.1038/35017038.

ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor

J P Borg  1 , S Marchetto, A Le Bivic, V Ollendorff, F Jaulin-Bastard, H Saito, E Fournier, J Adélaïde, B Margolis, D Birnbaum
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ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor

J P Borg et al. Nat Cell Biol. 2000 Jul.

Abstract

The ERBB receptors have a crucial role in morphogenesis and oncogenesis. We have identified a new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor ERBB2/HER2 in epithelia. ERBIN contains 16 leucine-rich repeats (LRRs) in its amino terminus and a PDZ (PSD-95/DLG/ZO-1) domain at its carboxy terminus, and belongs to a new PDZ protein family. The PDZ domain directly and specifically interacts with ERBB2/HER2. ERBIN and ERBB2/HER2 colocalize to the lateral membrane of human intestinal epithelial cells. The ERBIN-binding site in ERBB2/HER2 has a critical role in restricting this receptor to the basolateral membrane of epithelial cells, as mutation of the ERBIN-binding site leads to the mislocalization of the receptor in these cells. We suggest that ERBIN acts in the localization and signalling of ERBB2/HER2 in epithelia.

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Comment in

  • Collective nomenclature for LAP proteins.
    Bilder D, Birnbaum D, Borg JP, Bryant P, Huigbretse J, Jansen E, Kennedy MB, Labouesse M, Legouis R, Mechler B, Perrimon N, Petit M, Sinha P. Bilder D, et al. Nat Cell Biol. 2000 Jul;2(7):E114. doi: 10.1038/35017119. Nat Cell Biol. 2000. PMID: 10878817 No abstract available.

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