This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2000 Jul;2(7):463-5.

doi: 10.1038/35017108.

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

Z Zhang¹, P Nadeau, W Song, D Donoviel, M Yuan, A Bernstein, B A Yankner

Affiliations

PMID: 10878814
DOI: 10.1038/35017108

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

Z Zhang et al. Nat Cell Biol. 2000 Jul.

. 2000 Jul;2(7):463-5.

doi: 10.1038/35017108.

Authors

Z Zhang¹, P Nadeau, W Song, D Donoviel, M Yuan, A Bernstein, B A Yankner

Affiliation

¹ Department of Neurology, Harvard Medical School and Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA.

PMID: 10878814
DOI: 10.1038/35017108

No abstract available

PubMed Disclaimer

Similar articles

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645
Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH. Li G, et al. Mol Vis. 2003 May 1;9:179-83. Mol Vis. 2003. PMID: 12740567
Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
Selkoe DJ. Selkoe DJ. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11039-41. doi: 10.1073/pnas.211352598. Proc Natl Acad Sci U S A. 2001. PMID: 11572965 Free PMC article. Review.
Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
Wilson CA, Doms RW, Lee VM. Wilson CA, et al. J Neurosci Res. 2003 Nov 1;74(3):361-9. doi: 10.1002/jnr.10776. J Neurosci Res. 2003. PMID: 14598312 Review.

See all similar articles

Cited by

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins.
Dunys J, Kawarai T, Wilk S, St George-Hyslop P, Alves da Costa C, Checler F. Dunys J, et al. Biochem J. 2006 Mar 1;394(Pt 2):501-9. doi: 10.1042/BJ20051197. Biochem J. 2006. PMID: 16302845 Free PMC article.
Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing.
Liu Z, Thakar A, Santoro SW, Pratt KG. Liu Z, et al. Dev Neurobiol. 2018 Dec;78(12):1171-1190. doi: 10.1002/dneu.22638. Epub 2018 Oct 10. Dev Neurobiol. 2018. PMID: 30246932 Free PMC article.
Pharmacotherapeutic targets in Alzheimer's disease.
Biran Y, Masters CL, Barnham KJ, Bush AI, Adlard PA. Biran Y, et al. J Cell Mol Med. 2009 Jan;13(1):61-86. doi: 10.1111/j.1582-4934.2008.00595.x. Epub 2008 Nov 18. J Cell Mol Med. 2009. PMID: 19040415 Free PMC article. Review.
Transcriptional Regulation of TMP21 by NFAT.
Liu S, Zhang S, Bromley-Brits K, Cai F, Zhou W, Xia K, Mittelholtz J, Song W. Liu S, et al. Mol Neurodegener. 2011 Mar 7;6:21. doi: 10.1186/1750-1326-6-21. Mol Neurodegener. 2011. PMID: 21375783 Free PMC article.
Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.
Grigorenko AP, Moliaka YK, Plotnikova OV, Smirnov A, Nikishina VA, Goltsov AY, Gusev F, Andreeva TV, Nelson O, Bezprozvanny I, Rogaev EI. Grigorenko AP, et al. Oncotarget. 2017 May 30;8(47):82006-82026. doi: 10.18632/oncotarget.18299. eCollection 2017 Oct 10. Oncotarget. 2017. PMID: 29137240 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Other Literature Sources
- The Lens - Patent Citations Database