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Comment
. 2000 Jul;2(7):E121-3.
doi: 10.1038/35017129.

VHL takes HIF's breath away

W Krek
Comment

VHL takes HIF's breath away

W Krek. Nat Cell Biol. 2000 Jul.

Abstract

Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.

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