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. 2000:38 Suppl 2:S107-10.
doi: 10.1016/s0278-6915(00)00032-6.

The pharmacokinetics and metabolism of sucralose in the mouse

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The pharmacokinetics and metabolism of sucralose in the mouse

B A John et al. Food Chem Toxicol. 2000.

Abstract

The excretion and metabolism of (14)C-sucralose has been investigated in mice following intravenous and oral administration. A 20mg/kg intravenous dose was rapidly excreted mainly in the urine (80% in 5 days). After 100, 1500 and 3000mg/kg oral doses of (14)C-sucralose, means of 23%, 15% and 16% of the dose, respectively, were excreted in the urine during 5 days. Comparison with the intravenous dose indicated that 20-30% of the oral doses was absorbed. Sucralose was excreted almost entirely unchanged and represented more than 80-90% of the radioactivity in all urine and faeces samples. Only two minor metabolites were detected, representing 2-8% of urine radioactivity.

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