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Comment
. 2000 Jul 5;97(14):7670-2.
doi: 10.1073/pnas.97.14.7670.

Anfinsen comes out of the cage during assembly of the bacterial pilus

S Normark  1
Affiliations
Comment

Anfinsen comes out of the cage during assembly of the bacterial pilus

S Normark. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Pilin domain topology diagrams. Dashes indicate additional polypeptide not shown. (A) In donor strand complementation, the chaperone contributes its G1 strand (red) to complete the immunoglobulin-like fold of the subunit (white). The completed fold is noncanonical because the G1 strand runs parallel to the subunit C-terminal F strand. The N-terminal extension is shown as a blue strand. (B) After donor strand exchange, the N-terminal extension of one subunit completes the Ig fold of its neighbor in a canonical manner, as the N-terminal extension runs anti-parallel to the F strand. (C) Donor-strand-complemented FimH (dscFimH) was constructed by fusing the N-terminal extension of FimG (blue), which is predicted to complete the fold of FimH in the pilus, to the C terminus of FimH with a 4-amino-acid linker (yellow). The topology of the receptor-binding domain is not shown, but its position relative to the dscFimH pilin domain is indicated by the labeled box.
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Comment on

References

    1. Anfinsen C B. Science. 1973;181:223–230. - PubMed
    1. Barnhart M M, Pinkner J S, Soto G E, Sauer F G, Langermann S, Waksman G, Frieden C, Hultgren S J. Proc Natl Acad Sci USA. 2000;97:7709–7714. - PMC - PubMed
    1. Fenton W A, Horwich A L. Protein Sci. 1997;6:743–760. - PMC - PubMed
    1. Ellis R J, Hartl F U. FASEB J. 1996;10:20–26. - PubMed
    1. Shtilerman M, Lorimer G, Englander W. Science. 1999;284:822–825. - PMC - PubMed

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