A new direction for myosin

Abstract

Members of the myosin superfamily of actin-based motor proteins were previously thought to move only towards the barbed end of the actin filament. In an extraordinary reversal of this dogma, an abundant and widespread unconventional myosin known as myosin VI has recently been shown to move towards the pointed end of the actin filament - the opposite direction of all other characterized myosins. This discovery raises novel and intriguing questions about the molecular mechanisms of reversal and the biological roles of this 'backwards' myosin.