[Comparative characteristics of vanadium-containing compounds, possessing insulin-like effects]
- PMID: 10885036
[Comparative characteristics of vanadium-containing compounds, possessing insulin-like effects]
Abstract
The serum glucose concentration, HbAc1, fructoseamine, the activity of AST, ALT, amylase, glycogen content and glucokinase activity in rat hepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadate and vanadyl sulphate treatment. The improvement of this parameters were demonstrated after oral orthovanadate and vanadyl sulphate administration. However, insulin-mimetic properties of vanadyl sulphate were more marked in comparison with orthovanadate. LD-50 and cytotoxicity analysis in isolated hepatocytes showed that vanadyl sulphate was less toxic than orthovanadate.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials