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Comparative Study
. 2000 Mar-Apr;46(2):155-61.

[Comparative characteristics of vanadium-containing compounds, possessing insulin-like effects]

[Article in Russian]
Affiliations
  • PMID: 10885036
Comparative Study

[Comparative characteristics of vanadium-containing compounds, possessing insulin-like effects]

[Article in Russian]
M A Golubev et al. Vopr Med Khim. 2000 Mar-Apr.

Abstract

The serum glucose concentration, HbAc1, fructoseamine, the activity of AST, ALT, amylase, glycogen content and glucokinase activity in rat hepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadate and vanadyl sulphate treatment. The improvement of this parameters were demonstrated after oral orthovanadate and vanadyl sulphate administration. However, insulin-mimetic properties of vanadyl sulphate were more marked in comparison with orthovanadate. LD-50 and cytotoxicity analysis in isolated hepatocytes showed that vanadyl sulphate was less toxic than orthovanadate.

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