Use of 0.75 mg Levonorgestrel for postcoital contraception in Thailand

Abstract

Objective: This study identified the pattern of Levonorgestrel (LNG) use and self-reported side-effects among Thai women in Songkla.

Method: The eligible subjects were 100 Thai women who had used 0.75 mg LNG at least once in the past 12 months. The participants completed a questionnaire at the survey sites, which were seven pharmacies and five shopping malls.

Results: Eight percent of LNG users had never used any contraceptive methods other than day count and withdrawal. Thirty-nine percent took more than four tablets of LNG per month, which was the limit instructed in the label. Only 3% used LNG for emergency situations such as having unprotected intercourse or burst condom. At least 22% of subjects took LNG according to instructions which were last revised 2 years earlier. The study also revealed poor knowledge among the users on side-effects and limit of drug use. Compared to the previous studies, this study found a higher incidence of side-effects. Forty-four percent of subjects experienced cycle disturbances and 32% nausea, respectively.

Conclusion: The Thai FDA should seriously consider requiring manufacturers to revise labels of LNG to be consistent with those recommended by WHO.