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. 1976 Jul;73(7):2351-5.
doi: 10.1073/pnas.73.7.2351.

Nucleotide sequence of region preceding trp mRNA initiation site and its role in promoter and operator function

G N Bennett, M E Schweingruber, K D Brown, C Squires, C Yanofsky

Nucleotide sequence of region preceding trp mRNA initiation site and its role in promoter and operator function

G N Bennett et al. Proc Natl Acad Sci U S A. 1976 Jul.

Abstract

The nucleotide sequence of the region preceding the transcription initiation site of the tryptophan operon of Escherichia coli was determined. Essentially all of the trp operator precedes the transcribed portion of the operon. The deduced sequence contains the recognition site of endonuclease Hpa I. This site is protected from Hpa I cleavage by RNA polymerase and by trp repressor. Regions of 2-fold symmetry are present in the DNA sequence.

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References

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    1. Nature. 1974 Aug 2;250(465):394-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Aug;70(8):2335-9 - PubMed
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