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. 2000 Jul;25(3):254-5.
doi: 10.1038/76996.

Hepatocyte migration during liver development requires Prox1

B Sosa-Pineda  1 , J T Wigle, G Oliver
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Hepatocyte migration during liver development requires Prox1

B Sosa-Pineda et al. Nat Genet. 2000 Jul.

Abstract

Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.

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