Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1975 Jan;34(1):71-5.

Hayflick's hypothesis: an approach to in vivo testing

U Reincke, H Burlington, E P Cronkite, J Laissue
  • PMID: 1088946
Review

Hayflick's hypothesis: an approach to in vivo testing

U Reincke et al. Fed Proc. 1975 Jan.

Abstract

The experimental evidence relating to the hypothesis of finite cellular life is reviewed. It is emphasized that even if somatic cell production were limited its total potential would have to be vast to provide for extensive cellular regeneration. The actual limit of reproductive cell life would therefore not likely be reached in a normal life-span. It is proposed to test the hypothesis by deliberate exhaustion of stem-cell reserve, and iron-55 cytocide is described as an experimental system that might be applicable.

PubMed Disclaimer

Publication types

Substances