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. 2000 Jul;102(1):32-7.
doi: 10.1034/j.1600-0447.2000.102001032.x.

Brain imaging in childhood- and adolescence-onset schizophrenia associated with obsessive-compulsive symptoms

F Aoyama  1 , J Iida, M Inoue, H Iwasaka, S Sakiyama, K Hata, T Kishimoto
Affiliations

Brain imaging in childhood- and adolescence-onset schizophrenia associated with obsessive-compulsive symptoms

F Aoyama et al. Acta Psychiatr Scand. 2000 Jul.

Abstract

Objective: Childhood- and adolescence-onset schizophrenic patients with obsessive-compulsive symptoms (OCS) constitute a specific subgroup of schizophrenia. We performed magnetic resonance imaging in this group seeking evidence of neurodevelopmental insults.

Method: Thirty-two schizophrenic patients were compared with 19 controls. Schizophrenic subjects were divided into 15 patients with OCS (SOCS+ group; onset at 15.5 +/- 1.6 years) and 17 without OCS (SOCS- group; onset at 15.3 +/- 1.3 years). Areas of the hippocampus, frontal lobe, corpus callosum and putamen were analysed morphometrically.

Results: The left hippocampus was significantly smaller in the SOCS+ group than in the SOCS- and control groups.

Conclusion: Reduced size of the left hippocampus in the SOCS+ group supports a neurodevelopmental etiology in this subgroup.

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