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Review
. 2000;66(25):2419-26.
doi: 10.1016/s0024-3205(00)80001-6.

Recent advances in structure, binding sites with ligands and pharmacological function of beta-adrenoceptors obtained by molecular biology and molecular modeling

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Review

Recent advances in structure, binding sites with ligands and pharmacological function of beta-adrenoceptors obtained by molecular biology and molecular modeling

T Nagatomo et al. Life Sci. 2000.

Abstract

The structure, binding sites interacting with ligands and the physiological functions of G-protein coupled beta-adrenoceptors (beta-ARs) are being elucidated by molecular biology and molecular modeling studies. The definition given amino acid sequences of beta-ARs in molecular biology and the analysis of three-dimensional and functional binding sites interacting with ligands by molecular modeling may be important for identifying other functional beta-ARs in various tissues and discovering new drugs. Thus, this review focuses on the interaction sites for receptor-ligand and roles of functional beta-ARs as studied by molecular biology and molecular modeling.

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