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Review
. 2000 Aug;47(2):309-12.
doi: 10.1136/gut.47.2.309.

Interleukin 6 and liver regeneration

K L Streetz  1 , T Luedde, M P Manns, C Trautwein
Affiliations
Review

Interleukin 6 and liver regeneration

K L Streetz et al. Gut. 2000 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Intracellular cascades of the gp130 receptor. After interleukin 6 (IL-6) binding to gp80, two gp130 molecules homodimerise and activate JAK kinases which in turn phosphorylate the intracellular tyrosines of the gp130 receptor. Via the different phosphotyrosines, STAT1/3 and Ras dependent pathways are activated in the cell.
Figure 2
Figure 2
The role of interleukin 6 (IL-6) in hepatocyte proliferation after partial hepatectomy. After partial hepatectomy, tumour necrosis factor α (TNF-α) activates IL-6 expression, most likely in Kupffer cells. TNF-α and IL-6 via the gp80/gp130 receptor complex in turn activate intracellular pathways in liver cells which are essential for triggering hepatocyte proliferation after hepatectomy.
See this image and copyright information in PMC

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