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Clinical Trial
. 2000 Aug;44(8):2205-6.
doi: 10.1128/AAC.44.8.2205-2206.2000.

In vitro activity and fecal concentration of rifaximin after oral administration

Z D Jiang  1 , S Ke, E Palazzini, L Riopel, H Dupont
Affiliations
Clinical Trial

In vitro activity and fecal concentration of rifaximin after oral administration

Z D Jiang et al. Antimicrob Agents Chemother. 2000 Aug.

Abstract

Rifaximin showed moderately high MICs (the MIC at which 90% of the isolates tested were inhibited = 50 microg/ml) for 145 bacterial enteropathogens from patients with traveler's diarrhea acquired in Mexico during the summers of 1997 and 1998. Rifaximin concentrations in stool the day after oral administration (800 mg daily for 3 days) were high (average, 7,961 microg/g), proving the value of the drug.

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Figures

FIG. 1
FIG. 1
Stool concentrations of rifaximin in 39 patients with traveler's diarrhea tested after treatment with 800 mg of rifaximin/day. Bars, standard errors of the means.
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References

    1. Corazza G R, Ventrucci M, Strocchi A, Sorge M, Pranzo L, Pezzilli R, Gasbarrini G. Treatment of small intestine bacterial overgrowth with rifaximin, a non-absorbable rifamycin. J Int Med Res. 1988;16:312–316. - PubMed
    1. Descombe J J, Dubourg D, Picard M, Palazzini E. Pharmacokinetic study of rifaximin after oral administration in healthy volunteers. Int J Clin Pharmacol Res. 1994;16:51–56. - PubMed
    1. DuPont H L, Reves R R, Galindo E, Sullivan P S, Wood L V, Mendiola J G. Treatment of travelers' diarrhea with trimethoprim/sulfamethoxazole and with trimethoprim alone. N Engl J Med. 1982;307:841–844. - PubMed
    1. DuPont H L, Ericsson C D. Prevention and treatment of traveler's diarrhea. N Engl J Med. 1993;328:1821–1827. - PubMed
    1. DuPont H L, Ericsson C D, Mathewson J J, Palazzini E, DuPont M W, Jiang Z D, Mosavi A, de la Cabada F J. Rifaximin: a nonabsorbed antimicrobial in the therapy of travelers' diarrhea. Digestion. 1998;59:708–714. - PubMed

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